abstract：:Complex interactions between genetic and environmental factors exert a sustained influence on the pathogenesis of schizophrenia (SCZ). Adolescent social isolation is regarded as a typical paradigm for SCZ. However, the underlying pathological mechanisms are not fully understood. In this study, adolescent Sprague-Dawle...

journal_title：Brain research bulletin

authors： Sun L,Min L,Li M,Shao F,Wang W

更新日期：2018-09-01 00:00:00

abstract：:Chronic cerebral hypofusion (CCH) after bilateral carotid artery occlusion (2VO) causes cognitive damage and neuronal degeneration in the cortex and hippocampal CA1 area, and influences the oxygen and glucose supply in the brain which often results in metabolic alterations and oxidative stress. AMP-activated protein k...

journal_title：Brain research bulletin

authors： Chen Y,Guo Z,Peng X,Xie W,Chen L,Tan Z

更新日期：2018-06-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a degenerative disease with a progressive loss of motor neurons in the central nervous system (CNS). However, there are unsolved problems with the therapies for this disease. α-Lipoic acid (LA) is a natural, universal antioxidant capable of scavenging hydroxyl radicals as well as...

journal_title：Brain research bulletin

authors： Wang T,Cheng J,Wang S,Wang X,Jiang H,Yang Y,Wang Y,Zhang C,Liang W,Feng H

更新日期：2018-06-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease and is clinically characterised by the death of corticospinal motor neurons (CSMNs), spinal and brainstem MNs and the degeneration of the corticospinal tract. Degeneration of CSMNs and MNs leads inexorably to muscle wastage and weakness, ...

journal_title：Brain research bulletin

authors： Fogarty MJ

更新日期：2018-06-01 00:00:00

abstract：:The use of neurons induced from stem cells has been introduced as an effective strategy for promoting peripheral nerve regeneration (PNR). The evolution and role of native denervated Schwann cells (SCs) were often ignored when exploring the mechanisms underlying neural transplantation therapy for PNR. The aim of this ...

journal_title：Brain research bulletin

authors： Zheng Y,Huang C,Liu F,Lin H,Niu Y,Yang X,Zhang Z

更新日期：2018-05-01 00:00:00

abstract：:Previous findings showed that inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), degrading enzymes of anandamide (2-AEA) and 2-arachidonoylglycerol (2-AG), reduced the nonsteroidal anti-inflammatory drug-induced gastric lesions. The present study aimed to investigate: i./whether centra...

journal_title：Brain research bulletin

authors： Tóth VE,Fehér Á,Németh J,Gyertyán I,Zádori ZS,Gyires K

更新日期：2018-05-01 00:00:00

abstract：:After sustaining a traumatic brain injury (TBI), a person's ability to make daily decisions can be affected. Simple tasks such as, deciding what to wear are no longer effortless choices, but are instead difficult decisions. This study explored the use of a discrimination task with a magnesium treatment in order to exa...

journal_title：Brain research bulletin

authors： Young JM,Hoane MR

更新日期：2018-05-01 00:00:00

abstract：:Wnt signaling plays an important role in the adult brain function and its dysregulation has been implicated in some neurodegenerative pathways. Despite the functional role of the Wnt signaling in adult neural circuits, there is currently no evidence regarding the relationships between exogenously Wnt signaling activat...

journal_title：Brain research bulletin

authors： Ortiz-Matamoros A,Arias C

更新日期：2018-05-01 00:00:00

abstract：:Anxiety disorders and nicotine use are significant contributors to global morbidity and mortality as independent and comorbid diseases. Early-life stress, potentially via stress-induced hypothalamic-pituitary-adrenal axis (HPA) dysregulation, can exacerbate both. However, little is known about the factors that predisp...

journal_title：Brain research bulletin

authors： Caruso MJ,Reiss DE,Caulfield JI,Thomas JL,Baker AN,Cavigelli SA,Kamens HM

更新日期：2018-04-01 00:00:00

abstract：:Autophagy is the lysosome-mediated bulk degradation of cellular components for material recycling to maintain cellular homeostasis. Autophagy was initially regarded as a nonselective process, however, recent evidence indicates that this process can in fact be highly selective, especially for targeting and degrading or...

journal_title：Brain research bulletin

authors： Wu MY,Song JX,Wang SF,Cai CZ,Li M,Lu JH

更新日期：2018-03-01 00:00:00

abstract：:The effects of transcranial magnetic stimulation (TMS), natalizumab (nata), dimethyl fumarate (DMF) and dexamethasone (DEX) on clinical score and oxidative stress produced by a single dose of myelin oligodendrocyte glycoprotein (MOG) in tail of Dark Agouti rats was studied. TMS (60Hz and 0.7 mT), nata (5mg/kg), DMF (1...

journal_title：Brain research bulletin

authors： Medina-Fernandez FJ,Escribano BM,Luque E,Caballero-Villarraso J,Gomez-Chaparro JL,Feijoo M,Garcia-Maceira FI,Pascual-Leone A,Drucker-Colin R,Tunez I

更新日期：2018-03-01 00:00:00

abstract：:Extracellular matrix (ECM) molecules in the central nervous system form highly organized ECM structures around cell somata, axon initial segments, and synapses and play prominent roles in early development by guiding cell migration, neurite outgrowth and synaptogenesis, and by regulating closure of the critical period...

journal_title：Brain research bulletin

authors： Song I,Dityatev A

更新日期：2018-01-01 00:00:00

abstract：:Astrocytes are key active elements of the brain that contribute to information processing. They not only provide neurons with metabolic and structural support, but also regulate neurogenesis and brain wiring. Furthermore, astrocytes modulate synaptic activity and plasticity in part by controlling the extracellular spa...

journal_title：Brain research bulletin

authors： Dossi E,Vasile F,Rouach N

更新日期：2018-01-01 00:00:00

abstract：:Maternal immune activation during pregnancy is a risk factor for neurodevelopmental disorders, such as schizophrenia; however, a full mechanistic understanding has yet to be established. The activity of a transient cell population, the subplate neurons, is critical for the development of cortical inhibition and functi...

journal_title：Brain research bulletin

authors： Beamer E,Kovács G,Sperlágh B

更新日期：2017-10-01 00:00:00

abstract：:Data from clinical investigations and laboratory fundings have provided preliminary evidence for the effectiveness and safety of acupuncture therapy in depression. However, the mechanisms underlying the antidepressant response of acupuncture are not fully elucidated. To elucidate the potential effects of acupuncture f...

journal_title：Brain research bulletin

authors： Wang Y,Jiang H,Meng H,Lu J,Li J,Zhang X,Yang X,Zhao B,Sun Y,Bao T

更新日期：2017-09-01 00:00:00

abstract：:The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of Parkinson's disease (PD). PD is triggered by genetic alterations, environmental/occupational exposures and aging. However, the exact molecular mechani...

journal_title：Brain research bulletin

authors： Anandhan A,Jacome MS,Lei S,Hernandez-Franco P,Pappa A,Panayiotidis MI,Powers R,Franco R

更新日期：2017-07-01 00:00:00

abstract：:The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to...

journal_title：Brain research bulletin

authors： Wilkins HM,Swerdlow RH

更新日期：2017-07-01 00:00:00

abstract：:Peroxynitrite (ONOO-) is a strong biological oxidant formed by the diffusion-limited reaction of nitric oxide (NO-) and superoxide anion (O2-). It has long been theorized that peroxynitrite generation could be the cause in a number of pathological conditions ranging from atherosclerosis to inflammatory, autoimmune, he...

journal_title：Brain research bulletin

authors： Ramdial K,Franco MC,Estevez AG

更新日期：2017-07-01 00:00:00

abstract：:One of the important factors altering the degree of blood-brain barrier (BBB) disruption in cerebral ischemia is the anesthetic used. The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway has been reported to be involved in modulating BBB permeability and in isoflurane induced neuroprotection. This study was perf...

journal_title：Brain research bulletin

authors： Chi OZ,Mellender SJ,Kiss GK,Liu X,Weiss HR

更新日期：2017-05-01 00:00:00

abstract：:In the present study, multi-electrode array recording was used to examine dorsal horn activity following stimulation of primary afferents in a rat dorsal root attached-spinal cord slice preparation. The multi-electrode array probe was placed under the dorsal horn slice and local field potentials evoked by stimulation ...

journal_title：Brain research bulletin

authors： Yu F,Zhao ZY,He T,Yu YQ,Li Z,Chen J

更新日期：2017-05-01 00:00:00

abstract：:Rodent models for the study of neurogenic bladder dysfunction after spinal cord injury (SCI) are difficult to standardize, particularly when evaluating the specific contribution of the SCI to end-organ function. The purpose of this study was to evaluate the degree of bladder dysfunction associated with a highly reprod...

journal_title：Brain research bulletin

authors： Munoz A

更新日期：2017-05-01 00:00:00

abstract：:Brain trauma can activate an attenuation of connexin gap junction that is implicated in neuronal injury, but the underlying cellular mechanisms remain incompletely understood. Here, we aimed to study whether autophagy, a stress-response process for recycling of intracellular proteins and organelles, is involved in the...

journal_title：Brain research bulletin

authors： Chen W,Guo Y,Yang W,Zheng P,Zeng J,Tong W

更新日期：2017-05-01 00:00:00

abstract：:This study investigated the effect of green tea (GT) on short and long term declarative memory and oxidative damage induced by transient ischemia-reperfusion (IR) and intracerebral hemorrhage (ICH) in rats. Male Wistar rats were divided into 8 groups of 10 according the stroke type induced: Sham IR, Sham IR+GT, IR, IR...

journal_title：Brain research bulletin

authors： Altermann CDC,Souza MA,Schimidt HL,Izaguirry AP,Martins A,Garcia A,Santos FW,Mello-Carpes PB

更新日期：2017-05-01 00:00:00

abstract：:Although interleukin-1β (IL-1β) is a prototypical pro-inflammatory cytokine, the specific mechanisms underlying the role of its cognate receptor, the interleukin-1 receptor (IL-1R) in peripheral sensitization remain to be investigated. Since emerging evidence in the literature indicates that IL-1β can modulate membran...

journal_title：Brain research bulletin

authors： Kwon SG,Roh DH,Yoon SY,Choi SR,Choi HS,Moon JY,Kang SY,Beitz AJ,Lee JH

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:The effects of COX-2 inhibitors on seizure activity are controversial. The aim of the current study was to determine the post-treatment effect of aceclofenac on penicillin-induced experimental epilepsy. METHODS:Male Wistar rats were used in all experiments (n=18). The seizure activity was triggered by penicill...

journal_title：Brain research bulletin

authors： Taşkıran M,Taşdemir A,Ayyıldız N

更新日期：2017-04-01 00:00:00

abstract：:Studies have indicated that glutamate receptor subunit 3 peptide B antibodies (GluR3B Ab's) by directing against a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid subtype glutamate receptors (AMPARs) subunit 3 (GluR3B) was involved in the hippocampal neuron damage in the pathogenesis of epilepsy. Glutamate accumula...

journal_title：Brain research bulletin

authors： Liu Y,Chen Y,Du WT,Wu XX,Dong FX,Qu XB,Fan HB,Yao RQ

更新日期：2017-04-01 00:00:00

abstract：:Since the groundbreaking work of Ramon y Cajal, the cerebellar Purkinje cell has always represented an ideal model for studying the organization, development and function of synaptic circuits. Purkinje cells receive distinct types of glutamatergic and GABAergic synapses, each characterized by exquisite sub-cellular an...

journal_title：Brain research bulletin

authors： Sassoè-Pognetto M,Patrizi A

更新日期：2017-03-01 00:00:00

abstract：:Homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein (HERPUD1) is involved in endoplasmic reticulum stress response. Immense amounts of research showed HERPUD1 plays multiple roles in various models. In this work, we explored the role of HERPUD1 during the pathophysiolog...

journal_title：Brain research bulletin

authors： Ding W,Chen R,Wu C,Chen W,Zhang H,Fan X,Wang H,Ji Y,Xie L,Ning X,Shen L

更新日期：2017-01-01 00:00:00

abstract：:Methylphenidate (MPD) is a widely prescribed psychostimulants used for the treatment of attention deficit hyperactive disorder (ADHD). Unlike the psychostimulants cocaine and amphetamine, MPD does not exhibit direct actions on the serotonin transporter, however there is evidence suggesting that the therapeutic effects...

journal_title：Brain research bulletin

authors： Kharas N,Whitt H,Reyes-Vasquez C,Dafny N

更新日期：2017-01-01 00:00:00

abstract：:The primary visual pathway exhibits a symmetrical anatomical structure, initially arising from the left and right retinas, passing through the lateral geniculate nucleus, and finally projecting to the left and right primary visual cortices. However, to our knowledge, studies based on scalp EEG have not provided adequa...

journal_title：Brain research bulletin

authors： Wu Z,Wu Z

更新日期：2017-01-01 00:00:00

abstract：:The most severe manifestation of Herpes Simplex Type 1 virus (HSV-1) infection is encephalitis characterized by arousal impairment and seizures that can evolve to coma and death. Previous studies reported the involvement of suppressor of cytokine signaling (SOCS) proteins, specifically SOCS1 and SOCS3, in HSV-1 infect...

journal_title：Brain research bulletin

authors： da Cunha Sousa LF,Rachid MA,Lima GK,de Miranda AS,de Carvalho Vilela M,Lacerda Queiroz N,Rodrigues DH,Campos MA,Kroon EG,Machado FS,Teixeira AL

更新日期：2016-10-01 00:00:00

abstract：:The cytoskeleton is the major intracellular structure that determines the morphology of neurons and maintains their structural integrity. It is therefore not surprising that a disturbance of cytoskeletal structure and functionunderlies many neurodegenerative diseases. This special issue brings together current informa...

journal_title：Brain research bulletin

authors： Brandt R,Götz J

更新日期：2016-09-01 00:00:00

abstract：:Psychoactive drug use occurs in essentially all human societies. A range of disciplines contribute to our understanding of the influence of drugs upon the human world. For example pharmacology and neuroscience analyse biological responses to drugs, sociology examines social influences upon people's decisions to use dr...

journal_title：Brain research bulletin

authors： Wadley G

更新日期：2016-09-01 00:00:00

abstract：:Gamma-secretase (GS) is an enzyme complex that cleaves numerous substrates, and it is best known for cleaving amyloid precursor protein (APP) to form amyloid-beta (Aβ) peptides. Aberrant cleavage of APP can lead to Alzheimer's disease, so much research has been done to better understand GS structure and function in ho...

journal_title：Brain research bulletin

authors： Carroll CM,Li YM

更新日期：2016-09-01 00:00:00

abstract：:Microtubules are essential for the development and maintenance of axons and dendrites throughout the life of the neuron, and are vulnerable to degradation and disorganization in a variety of neurodegenerative diseases. Microtubules, polymers of tubulin heterodimers, are intrinsically polar structures with a plus end f...

journal_title：Brain research bulletin

authors： Matamoros AJ,Baas PW

更新日期：2016-09-01 00:00:00

abstract：:Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly understood; current nosological concepts are largely based on these molecular signatures of protein aggregates which also provide valua...

journal_title：Brain research bulletin

authors： Arendt T,Stieler JT,Holzer M

更新日期：2016-09-01 00:00:00

abstract：:Methoxetamine (MXE) is a novel psychoactive compound (NPS) that emerged in 2010 as a substitute for the dissociative anaesthetic ketamine. MXE has a reputation of carrying a lower risk of harm than ketamine, however a number of deaths have been reported. Currently very little is known about the psychopharmacological e...

journal_title：Brain research bulletin

authors： Horsley RR,Lhotkova E,Hajkova K,Jurasek B,Kuchar M,Palenicek T

更新日期：2016-09-01 00:00:00

abstract：:Accumulating evidence points to the amyloid-β (Aβ) peptide as the culprit in the pathogenesis of Alzheimer's disease (AD). β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is a protease that is responsible for initiating Aβ production. Although precise mechanisms that trigger Aβ accumulation remain unc...

journal_title：Brain research bulletin

authors： Ohno M

更新日期：2016-09-01 00:00:00

abstract：:The development of morphine-induced antinociceptive tolerance limits its therapeutic efficacy in pain management. Atorvastatin, or competitive inhibitor of 3-hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase, is mainstay agent in hypercholesterolemia treatment. Beyond the cholesterol-lowering activity, exploratio...

journal_title：Brain research bulletin

authors： Hassanipour M,Amini-Khoei H,Shafaroodi H,Shirzadian A,Rahimi N,Imran-Khan M,Rezayat SM,Dehpour A

更新日期：2016-07-01 00:00:00

abstract：:Taurine is an abundant amino acid in the nervous system, which has been proved to possess antioxidation, osmoregulation and membrane stabilization. Previously it has been demonstrated that taurine exerts ischemic brain injury protective effect. This study was designed to investigate whether the protective effect of ta...

journal_title：Brain research bulletin

authors： Zhu XY,Ma PS,Wu W,Zhou R,Hao YJ,Niu Y,Sun T,Li YX,Yu JQ

更新日期：2016-06-01 00:00:00